JUHEL C. (1), TOSINI F. (1), STEIB M. (1), WILS D.(2), DEREMAUX L. (1), LAIRON D.(3), CARA L.(1)
(1) Avantage Nutrition, 116, chemin des Sables Jaunes, F-13012 Marseille (FRANCE)
(2) Groupe Roquette, F-62080 Lestrem (FRANCE)
(3) UMR INSERM 476 – INRA 1260, Faculté de Médecine, 27, bd Jean Moulin, F-13385 Marseille (FRANCE)
NUTRIOSE® FB is a newly launched soluble fiber obtained from wheat starch dextrinization. This non-viscous glucose polymer is characterized by several non-digestible linkages. Previous studies have shown that NUTRIOSE® FB is poorly hydrolysed and absorbed in the small intestine, and well fermented along the colon.
Aim:
The present study investigated the effect of this soluble non-viscous dietary fiber source on cholesterolemia and lipid metabolism in moderately hypercholesterolemic hamsters.
Methods:
5 groups of 8 Golden Syrian hamsters were randomly assigned to receive for 3 weeks either a standard diet without cholesterol, or 0.25% cholesterol-enriched diets providing different amounts of NUTRIOSE® FB, i.e. no (control cellulose: CHO), 3% (N3), 6% (N6) or 9% (N9) (w/w).
Results:
As compared to the CHO diet, the 9% NUTRIOSE® FB diet significantly (P<0.05) lowered the plasma and LDL cholesterol by 14.5% and 23.8%, respectively. The LDL-cholesterol lowering effect was also significant with the 6 % dose (-21.4%, P<0.05). All NUTRIOSE® FB-containing diets prevented hepatic cholesterol accumulation (-10 to -20%, P<0.05) and increased bile cholesterol (+47 to +68%, P<0.05) and phospholipids (30 to 45%, P<0.05) concentrations. Rate of dietary cholesterol absorption and faecal excretion of neutral sterols and bile salts were assessed in CHO and N9 groups. The 9 % NUTRIOSE® FB diet significantly decreased the rate of dietary cholesterol absorption (-25%, P<0.05) and markedly stimulated faecal neutral sterol (+81%, P<0.05) and bile salts (+220%, P<0.05) excretion.
Conclusion:
These data suggest that the cholesterol-lowering effect of NUTRIOSE® FB is likely related to the reduced cholesterol and bile salt absorptions, and support its use as a new dietary functional fiber to prevent moderate hypercholesterolemia.