Nutritional Sciences at Roquette
As a result of clinical research undergoing at Roquette on the nutritional properties of our ingredients, probably related to the effect of this soluble fiber in the gut, it has been demonstrated that NUTRIOSE® was a useful tool both for body composition improvement and for metabolic improvement in volunteers with slight overweight.
In a first publication, L. Guerin-Deremaux and coll1. have described the effects of NUTRIOSE® dietary fiber supplementation on body weight, body composition, energy intake, and hunger in 120 overweight men. The volunteers received either NUTRIOSE® or a maltodextrin (control) at a dosage of 17g twice daily for 12 weeks. Body weight, body composition were performed at 0, 4, 8 and 12 weeks while daily energy intake and hunger were assessed every 3 days. Test subjects had reductions in body weight (1.5 kg, p<0.001), BMI (0.5 kg/m2, p<0.001) and body fat percentage (0.3%, p<0.001) versus controls. NUTRIOSE® supplementation resulted in a lower daily energy intake (3,079 kJ/day, p<0.001) with differences noted between groups as early as 3 days. Test subjects reported less hunger across the study period vs. controls (p<0.01).
In parallel, the influence of NUTRIOSE® dietary fiber supplementation on insulin resistance and determinants of metabolic syndrome in these overweight men was examined2 . All markers of glucose metabolism improved in the NUTRIOSE® group, with increases in adiponectin and reductions in glucose, insulin, homeostasis model assessment-estimated insulin resistance, glycosylated hemoglobin, and glycated albumin (all p < 0.01). Similarly, all lipid measures improved with increases in high-density lipoprotein cholesterol and reductions in total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and triglycerides (all p < 0.01). No changes were observed in systolic blood pressure between groups. Most components of glucose metabolism and the lipid profile were significantly better in the NUTRIOSE® than in the control subjects. No adverse events or gastrointestinal complaints were reported in either group.
In conclusion, supplementation with NUTRIOSE® for 12 weeks is well tolerated, results in body composition improvements, reduces body weight, energy intake and hunger in overweight men, lowers insulin resistance, and improves determinants of metabolic syndrome in overweight men.
As Metabolic Syndrome is a huge concern worldwide and highly prevalent, and as overweight and obesity are actually impacting the health of billions people worldwide, the nutritional interest of ingredients such as NUTRIOSE®, a soluble resistant dextrin with prebiotic properties, is obvious. It can therefore be a useful tool in such a context, in addition to physical exercise.
Dr Catherine Lefranc-Millot, Nutrition Direction
1 Guerin-Deremaux L, Li S, Pochat M, Wils D, Mubasher M, Reifer C and Miller LE Effects of NUTRIOSE® dietary fiber supplementation on body weight, body composition, energy intake, and hunger in overweight men. International Journal of Food Sciences and Nutrition, 2011 (in press)
2 Li S, Guerin-Deremaux L, Pochat M, Wils D, Reifer C and Miller LE. NUTRIOSE® dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study. Appl. Physiol. Nutr. Metab. 2010, 35: 773–782